EVOLUTE Resin-based sorbents
Minimize method development time with EVOLUTE® sorbents
Evolute® sample preparation products are advanced water-wettable polymeric sorbents for generic extraction of analytes from biological samples. Based on a polystyrene-divinylbenzene (PS-DVB) sorbent, Evolute has optimized pore structure that minimize the retention of endogenous interferences.
The solution to all your sample preparation needs :
> EVOLUTE® ABN for extraction of Acidic, Basic and Neutral drugs
> EVOLUTE® CX for extraction of Basic drugs
> EVOLUTE® WCX for extraction of a range of strongly basic analytes and quaternary amines
> EVOLUTE® AX for extraction of acidic analytes
EVOLUTE® ABN for extraction of Acidic, Basic and Neutral drugs
EVOLUTE ABN is an advanced water-wettable polymer-based sorbent that extracts acidic, basic and neutral analytes from biological fluids and other aqueous matrices. Developed specifically for analyte quantification by LC-MS/MS, EVOLUTE products provide a highly effective solution to the problems of ion suppression and matrix effects from dirty extracts. These high performance products allow scientists to use a generic approach for a wide range of compounds, thus reducing method development time while producing super clean extracts.
• Minimal ion suppression
• Four times higher signal intensity in LC-MS/MS
• Fast, simple generic methodology
• High, reproducible recoveries for a wide range of analytes
EVOLUTE® CX for extraction of Basic drugs
EVOLUTE CX is a mixed-mode sorbent for the extraction of basic analytes from biological fluids and other aqueous matrices. The mixed mode consists of a surface modified polystyrene-divynilbenzene (non polar) and sulfonic acid groups (cation exchange). This product uses a generic approach for a wide range of basic compounds and is less matrix dependant vs. 100% ion exchange.
• More robust procedures
• Sorbent designed to provide multiple interactions
• Interference elution regime removes additional interference classes
• Mixed-mode SPE provides enhanced extract purity for ionisable analytes
EVOLUTE® WCX for extraction of strongly basic analytes
EVOLUTE WCX is a weak cation exchange mixed-mode resin-based SPE sorbent that extracts a range of strongly basic analytes and quaternary amines from biological fluids and other aqueous matrices using a generic procedure which minimizes method development time. EVOLUTE WCX removes matrix components such as proteins, salts, non-ionizable interferences and phospholipids, delivering cleaner extracts with reproducible recoveries for accurate quantitation.
• Removal of proteins, salts, non-ionizable interferences and phospholipids
• Fast, simple generic methodology
• Allows for acidic elution conditions suitable for LC-MS analysis
• Minimal ion suppression
• High, reproducible recoveries for a wide range of basic drugs and quarternary amines
EVOLUTE® AX for extraction of acidic analytes
EVOLUTE® AX mixed-mode resin-based SPE sorbent extracts a range of acidic analytes from biological fluids and other aqueous matrices using a generic procedure which minimizes method development time. EVOLUTE AX removes matrix components such as proteins, salts, nonionisable interferences and phospholipids, delivering cleaner extracts with reproducible recoveries for accurate quantitation.
• Removal of proteins, salts, non-ionizable interferences and phospholipids
• Fast, simple generic methodology
• Minimal ion suppression
• High, reproducible recoveries for a wide range of acidic analytes