The complement cascade, consisting of ~20 serum proteins, plays an important role in the body´s immunological defense system. Complement activity in human sera can provide important information in the diagnosis of many diseases. Clinically, complement activity is a direct indicator of abnormalities of the complement system, and is different from immunoreactive components of the system. Complement activity has been correlated with the active stage of systemic lupus erythematosus, rheumatoid arthritis, cryoglobulinemia-vasculitis, some form of nephritis, and inherited deficiencies of the complement system.
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