It is well known, that inflammatory processes play an important role in the pathogenesis of atherosclerosis. Established risk factors account for part of the cardiovascular diseases only. Lp-PLA2, a new reliable marker in the atherosclerotic risk assessment, is able to close this diagnostic gap.
Studies provide strong evidence, that the presence of Lp-PLA2 is associated with an increased risk of cardiac death, myocardial infarction, acute coronary syndrome and ischemic stroke. Increased Lp-PLA2 concentrations can be found in vulnerable atherosclerotic plaques and allow discrimination between morphologically identical stable and unstable plaques. Lp-PLA2 testing is an excellent complement to angiography because it detects very small plaques not visible by medical imaging. Unlike traditional atherosclerotic risk markers Lp-PLA2 is highly specifc for vascular inflammation, has low biological variability, and plays a causative role in atherosclerotic plaque inflammation. Continue reading »